Craving a comforting, family-friendly meal that’s both easy to make and incredibly delicious? Look no further than the Bisquick chicken casserole. Loved by home cooks, busy parents, and food enthusiasts alike, this versatile dish is perfect for any night of the week. Not only is it quick to put together, but it also allows for creative twists to suit your family’s tastes.

bisquick chicken casserole

Ingredients You'll Need:

  • 2 cups cooked chicken, shredded or diced
  • 1 cup Bisquick mix
  • 1 cup milk
  • 1/2 cup sour cream
  • 1 can (10.5 oz) cream of chicken soup
  • 1 cup frozen mixed vegetables (optional)
  • 1/2 cup shredded cheese (cheddar or your preferred type)
  • 1/2 teaspoon garlic powder
  • Salt and pepper to taste

Step-by-Step Instructions:

Step 1: Preheat Your Oven

Preheat your oven to 375°F (190°C). This ensures that your casserole bakes evenly, creating a perfectly golden top layer.

Step 2: Prepare the Bisquick Mixture

In a mixing bowl, combine 1 cup of Bisquick mix, 1 cup of milk, and 1/2 cup of sour cream. Stir until you get a smooth batter. This will form the base and top layer of your casserole.

Step 3: Layer the Ingredients

  • First Layer: Spread the shredded or diced chicken evenly across the bottom of a greased casserole dish.
  • Second Layer: Pour the can of cream of chicken soup over the chicken. If you're adding frozen mixed vegetables, sprinkle them evenly over the soup.
  • Third Layer: Pour the Bisquick mixture over the top, spreading it out to cover the entire dish.

Step 4: Add Seasonings and Cheese

Sprinkle 1/2 teaspoon of garlic powder, and salt and pepper to taste over the Bisquick layer. Top it all off with 1/2 cup of shredded cheese.

Step 5: Bake

Place the casserole dish in the preheated oven and bake for 35-40 minutes, or until the top is golden brown and a toothpick inserted into the center comes out clean.

Tips for Perfect Chicken:

  • Choosing the Chicken: Opt for boneless, skinless chicken breasts or thighs for ease of preparation. Rotisserie chicken is a great time-saver.
  • Preparing the Chicken: Season your chicken with salt, pepper, and garlic powder before cooking it to enhance the flavor. Baking, boiling, or sautéing are all excellent methods.

Alternative Ingredients:

  • Gluten-Free: Use a gluten-free Bisquick mix.
  • Dairy-Free: Substitute the sour cream with dairy-free yogurt and use a can of coconut milk instead of regular milk.
  • Vegetarian: Replace the chicken with a can of chickpeas or a cup of cooked quinoa for a plant-based version.

Serving Suggestions:

  • Side Dishes: Pair your casserole with a fresh green salad, garlic bread, or steamed vegetables for a complete meal.
  • Storage Tips: Leftovers can be stored in an airtight container in the refrigerator for up to 3 days. Reheat in the oven or microwave until heated through.


This Bisquick chicken casserole is sure to become a family favorite, thanks to its hearty ingredients and simple preparation. Whether you're feeding a crowd or looking for an easy weeknight meal, this dish has you covered. Give it a try, and don't forget to share your favorite variations with us!

Happy cooking!

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